InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PYCR2

Summary

InnateDB Protein

IDBP-106982.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PYCR2

Protein Name

pyrroline-5-carboxylate reductase family, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000342502

InnateDB Gene

IDBG-106980 (PYCR2)

Protein Structure

UniProt Annotation

Function

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. {ECO:0000269PubMed:2722838, ECO:0000269PubMed:6894153}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:2722838}.

Disease Associations

Tissue Specificity

Detected in erythrocytes (at protein level). {ECO:0000269PubMed:2722838, ECO:0000269PubMed:6894153}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004735	pyrroline-5-carboxylate reductase activity

Biological Process

GO:0006561	proline biosynthetic process
GO:0055114	oxidation-reduction process
GO:0055129	L-proline biosynthetic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000304 Pyrroline-5-carboxylate reductase
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF03807

PRINTS

PIRSF

PIRSF000193

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96C36