InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGFBP1

Summary

InnateDB Protein

IDBP-10717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGFBP1

Protein Name

fibroblast growth factor binding protein 1

Synonyms

FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17;

Species

Homo sapiens

Ensembl Protein

ENSP00000371770

InnateDB Gene

IDBG-10715 (FGFBP1)

Protein Structure

UniProt Annotation

Function

Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. {ECO:0000269PubMed:11509569, ECO:0000269PubMed:15806171, ECO:0000269PubMed:1885605, ECO:0000269PubMed:9334727}.

Subcellular Localization

Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.

Disease Associations

Tissue Specificity

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo- epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. {ECO:0000269PubMed:11148217, ECO:0000269PubMed:15806171, ECO:0000269PubMed:1885605}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway