Version 5.4
Homo sapiens Protein: HIST3H2A
Summary
InnateDB Protein IDBP-107268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIST3H2A
Protein Name histone cluster 3, H2a
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355656
InnateDB Gene IDBG-107266 (HIST3H2A)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0006337 nucleosome disassembly
GO:0070914 UV-damage excision repair
Cellular Component
GO:0000786 nucleosome
GO:0000788 nuclear nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR002119 Histone H2A
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS PR00620
PIRSF
SMART SM00414
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L7L0
PhosphoSite PhosphoSite-Q7L7L0
TrEMBL
UniProt Splice Variant
Entrez Gene 92815
UniGene Hs.743797
RefSeq NP_254280
HUGO HGNC:20507
OMIM 615015
CCDS CCDS1573
HPRD 13660
IMGT
EMBL AK311930 AL139288 AY131974 BC082269 CH471098
GenPept AAN59960 BAG34871 CAI23331 EAW69878

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca