InnateDB Protein
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IDBP-107278.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNF187
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Protein Name
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ring finger protein 187
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000306396
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InnateDB Gene
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IDBG-107274 (RNF187)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. {ECO:0000269PubMed:20852630}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:20852630}. Nucleus {ECO:0000269PubMed:20852630}. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0008284
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positive regulation of cell proliferation
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0051865
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protein autoubiquitination
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GO:0070936
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protein K48-linked ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
IPR018957
Zinc finger, C3HC4 RING-type
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PFAM |
PF13639
PF14634
PF00097
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q5TA31
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PhosphoSite |
PhosphoSite-Q5TA31
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
149603
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UniGene |
Hs.649803
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RefSeq |
NP_001010858
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HUGO |
HGNC:27146
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OMIM |
613754
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AL139288
BC012758
BC064481
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GenPept |
AAH12758
AAH64481
CAI23328
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