Version 5.4
Homo sapiens Protein: TARBP1
Summary
InnateDB Protein IDBP-107512.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TARBP1
Protein Name TAR (HIV-1) RNA binding protein 1
Synonyms TRM3; TRP-185; TRP185;
Species Homo sapiens
Ensembl Protein ENSP00000040877
InnateDB Gene IDBG-107510 (TARBP1)
Protein Structure
UniProt Annotation
Function Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA. {ECO:0000269PubMed:7638159, ECO:0000269PubMed:8626763, ECO:0000269PubMed:8846792}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0008173 RNA methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006396 RNA processing
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001537 tRNA/rRNA methyltransferase, SpoU type
IPR016024 Armadillo-type fold
IPR029028 Alpha/beta knot methyltransferases
PFAM PF00588
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13395
PhosphoSite PhosphoSite-Q13395
TrEMBL
UniProt Splice Variant
Entrez Gene 6894
UniGene Hs.609704
RefSeq NP_005637
HUGO HGNC:11568
OMIM 605052
CCDS CCDS1601
HPRD 05445
IMGT
EMBL AL136124 AL355472 U38847
GenPept AAC50379 CAI22828 CAI22931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca