InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNG4

Summary

InnateDB Protein

IDBP-107560.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNG4

Protein Name

guanine nucleotide binding protein (G protein), gamma 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355557

InnateDB Gene

IDBG-107558 (GNG4)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Brain, kidney, pancreas, skeletal muscle and faintly in cardiac muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0030308	negative regulation of cell growth
GO:0044281	small molecule metabolic process
GO:0071377	cellular response to glucagon stimulus