InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNST

Summary

InnateDB Protein

IDBP-107846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNST

Protein Name

consortin, connexin sorting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355470

InnateDB Gene

IDBG-107844 (CNST)

Protein Structure

UniProt Annotation

Function

Required for targeting of connexins to the plasma membrane. {ECO:0000269PubMed:19864490}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19864490}; Single-pass membrane protein {ECO:0000269PubMed:19864490}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:19864490}; Single-pass membrane protein {ECO:0000269PubMed:19864490}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269PubMed:19864490}. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans- Golgi network and the cell membrane via the secretory pathway.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019902	phosphatase binding
GO:0071253	connexin binding

Biological Process

GO:0010923	negative regulation of phosphatase activity
GO:0042998	positive regulation of Golgi to plasma membrane protein transport

Cellular Component

GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030133	transport vesicle
GO:0043234	protein complex