InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AHCTF1

Summary

InnateDB Protein

IDBP-107861.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AHCTF1

Protein Name

AT hook containing transcription factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355465

InnateDB Gene

IDBG-107859 (AHCTF1)

Protein Structure

UniProt Annotation

Function

Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269PubMed:17098863, ECO:0000269PubMed:17235358}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus matrix {ECO:0000250}. Chromosome, centromere, kinetochore. Nucleus, nucleoplasm. Nucleus, nuclear pore complex. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107- 160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0006355	regulation of transcription, DNA-templated
GO:0015031	protein transport
GO:0051028	mRNA transport
GO:0051292	nuclear pore complex assembly

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0031080	nuclear pore outer ring
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome