InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHN2

Summary

InnateDB Protein

IDBP-10874.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHN2

Protein Name

chimerin (chimaerin) 2

Synonyms

ARHGAP3; BCH; CHN2-3; RHOGAP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000222792

InnateDB Gene

IDBG-10872 (CHN2)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.

Subcellular Localization

Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0009967	positive regulation of signal transduction
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR008936 Rho GTPase activation protein
IPR017356 N-chimaerin
IPR020454 Diacylglycerol/phorbol-ester binding

PFAM

PF00620
PF00017
PF14633
PF00130

PRINTS

PR00401
PR00008

PIRSF

PIRSF038015

SMART

SM00324
SM00252
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References