InnateDB Protein
|
IDBP-11076.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MED28
|
Protein Name
|
mediator complex subunit 28
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000237380
|
InnateDB Gene
|
IDBG-11074 (MED28)
|
Protein Structure
|
|
Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269PubMed:15467741}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:15467741}. Cytoplasm {ECO:0000269PubMed:15467741}. Membrane {ECO:0000269PubMed:15467741}; Peripheral membrane protein {ECO:0000269PubMed:15467741}. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver. {ECO:0000269PubMed:15467741}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
106
[view]
|
Protein-Protein |
105
[view]
|
Protein-DNA |
0
|
Protein-RNA |
1
[view]
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR021640
Mediator complex, subunit Med28
|
PFAM |
PF11594
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9H204
|
PhosphoSite |
PhosphoSite-Q9H204
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
80306
|
UniGene |
Hs.605260
|
RefSeq |
NP_079481
|
HUGO |
HGNC:24628
|
OMIM |
610311
|
CCDS |
CCDS33963
|
HPRD |
14381
|
IMGT |
|
EMBL |
AF317680
AF318059
AF321617
AF358829
BC011936
|
GenPept |
AAG38612
AAH11936
AAK11563
AAK32724
AAL26906
|
|
|