Version 5.4
Homo sapiens Protein: KREMEN2
Summary
InnateDB Protein IDBP-11182.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KREMEN2
Protein Name kringle containing transmembrane protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000322079
InnateDB Gene IDBG-11178 (KREMEN2)
Protein Structure
UniProt Annotation
Function Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity). {ECO:0000250UniProtKB:Q8K1S7}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000001 Kringle
IPR000859 CUB domain
IPR002889 Carbohydrate-binding WSC
IPR013806 Kringle-like fold
IPR013994 Carbohydrate-binding WSC, subgroup
PFAM PF00051
PF00431
PF01822
PRINTS
PIRSF
SMART SM00130
SM00042
SM00321
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NCW0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 79412
UniGene Hs.661128
RefSeq NP_078783
HUGO HGNC:18797
OMIM 609899
CCDS CCDS10484
HPRD 13933
IMGT
EMBL AB086355 AB086356 AB086357 AB086405 AC004235 AK027669 AK075033 AK301953 BC003533 BC009383 CH471112
GenPept AAH03533 AAH09383 BAB55281 BAC00823 BAC00824 BAC00825 BAC00872 BAC11365 BAG63368 EAW85449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca