InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INMT

Summary

InnateDB Protein

IDBP-11246.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INMT

Protein Name

indolethylamine N-methyltransferase

Synonyms

TEMT;

Species

Homo sapiens

Ensembl Protein

ENSP00000013222

InnateDB Gene

IDBG-407426 (INMT)

Protein Structure

UniProt Annotation

Function

Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds. {ECO:0000250, ECO:0000269PubMed:10552930}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain. {ECO:0000269PubMed:10552930}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004790	thioether S-methyltransferase activity
GO:0008168	methyltransferase activity
GO:0016740	transferase activity
GO:0030748	amine N-methyltransferase activity