Version 5.4
Homo sapiens Protein: PEBP4
Summary
InnateDB Protein IDBP-11289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEBP4
Protein Name phosphatidylethanolamine-binding protein 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000256404
InnateDB Gene IDBG-11287 (PEBP4)
Protein Structure
UniProt Annotation
Function Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization. {ECO:0000269PubMed:15302887}.
Subcellular Localization Lysosome {ECO:0000269PubMed:15302887}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Highly expressed in tumor cells. {ECO:0000269PubMed:15302887}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005764 lysosome
Protein Structure and Domains
PDB ID
InterPro IPR008914 Phosphatidylethanolamine-binding protein PEBP
PFAM PF01161
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96S96
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 157310
UniGene Hs.491242
RefSeq NP_659399
HUGO HGNC:28319
OMIM 612473
CCDS CCDS43724
HPRD 11424
IMGT
EMBL AY037148 AY359109 AY730275 BC020779
GenPept AAH20779 AAK67629 AAQ89467 AAW56965

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca