InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GALK2

Summary

InnateDB Protein

IDBP-11404.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALK2

Protein Name

galactokinase 2

Synonyms

GK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000316632

InnateDB Gene

IDBG-11402 (GALK2)

Protein Structure

UniProt Annotation

Function

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. {ECO:0000269PubMed:16006554}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004335	galactokinase activity
GO:0005524	ATP binding
GO:0033858	N-acetylgalactosamine kinase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006012	galactose metabolic process
GO:0046835	carbohydrate phosphorylation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000705 Galactokinase
IPR006204 GHMP kinase N-terminal domain
IPR006206 Mevalonate/galactokinase
IPR013750 GHMP kinase, C-terminal domain
IPR019539 Galactokinase galactose-binding domain
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF00288
PF08544
PF10509

PRINTS

PR00473
PR00959

PIRSF

PIRSF000530

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt