Version 5.4
Homo sapiens Protein: CEP76
Summary
InnateDB Protein IDBP-1161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP76
Protein Name centrosomal protein 76kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262127
InnateDB Gene IDBG-1159 (CEP76)
Protein Structure
UniProt Annotation
Function Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. {ECO:0000269PubMed:19460342}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Does not localize along the ciliary axoneme.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
Experimentally validated
Total 111 [view]
Protein-Protein 111 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0046599 regulation of centriole replication
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAP6
PhosphoSite PhosphoSite-Q8TAP6
TrEMBL
UniProt Splice Variant
Entrez Gene 79959
UniGene Hs.733687
RefSeq NP_079175
HUGO HGNC:25727
OMIM
CCDS CCDS11861
HPRD 12694
IMGT
EMBL AK022604 AK301964 AK303117 AL833727 AP005482 BC026307 CH471113 EF445040
GenPept AAH26307 ACA06091 BAB14123 BAG63377 BAG64223 CAH56252 EAX01543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca