InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR125

Summary

InnateDB Protein

IDBP-11639.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR125

Protein Name

G protein-coupled receptor 125

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000334952

InnateDB Gene

IDBG-11637 (GPR125)

Protein Structure

UniProt Annotation

Function

Orphan receptor.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000832 GPCR, family 2, secretin-like
IPR001611 Leucine-rich repeat
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003591 Leucine-rich repeat, typical subtype
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR017981 GPCR, family 2-like

PFAM