InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCY2

Summary

InnateDB Protein

IDBP-11796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCY2

Protein Name

adenylate cyclase 2 (brain)

Synonyms

AC2; HBAC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000342952

InnateDB Gene

IDBG-11792 (ADCY2)

Protein Structure

UniProt Annotation

Function

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004016	adenylate cyclase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008179	adenylate cyclase binding
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006171	cAMP biosynthetic process
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009190	cyclic nucleotide biosynthetic process
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0055085	transmembrane transport
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0043234	protein complex
GO:0045121	membrane raft