InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOD3

Summary

InnateDB Protein

IDBP-11878.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOD3

Protein Name

superoxide dismutase 3, extracellular

Synonyms

EC-SOD;

Species

Homo sapiens

Ensembl Protein

ENSP00000371554

InnateDB Gene

IDBG-11874 (SOD3)

Protein Structure

UniProt Annotation

Function

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Subcellular Localization

Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.

Disease Associations

Tissue Specificity

Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004784	superoxide dismutase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0006801	superoxide metabolic process
GO:0006979	response to oxidative stress
GO:0019430	removal of superoxide radicals
GO:0046688	response to copper ion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005796	Golgi lumen
GO:0005802	trans-Golgi network
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome