Version 5.4
Homo sapiens Protein: SEH1L
Summary
InnateDB Protein IDBP-1206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEH1L
Protein Name SEH1-like (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262124
InnateDB Gene IDBG-1204 (SEH1L)
Protein Structure
UniProt Annotation
Function Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway. {ECO:0000269PubMed:15146057, ECO:0000269PubMed:17363900, ECO:0000269PubMed:23723238}.
Subcellular Localization Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0006999 nuclear pore organization
GO:0007077 mitotic nuclear envelope disassembly
GO:0007080 mitotic metaphase plate congression
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0015031 protein transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0044281 small molecule metabolic process
GO:0051028 mRNA transport
GO:0051315 attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
GO:0055085 transmembrane transport
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005635 nuclear envelope
GO:0005829 cytosol
GO:0031080 nuclear pore outer ring
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EE3
PhosphoSite PhosphoSite-Q96EE3
TrEMBL K7EPZ5
UniProt Splice Variant
Entrez Gene 81929
UniGene Hs.731967
RefSeq NP_112493
HUGO HGNC:30379
OMIM 609263
CCDS CCDS45832
HPRD 15319
IMGT
EMBL AF136976 AF255625 AF431970 AF514996 AK056940 AK291226 AP002449 BC012430
GenPept AAG49437 AAH12430 AAM21169 AAM44214 AAM76707 BAB71317 BAF83915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca