InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRC3

Summary

InnateDB Protein

IDBP-12137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRC3

Protein Name

NLR family, CARD domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352039

InnateDB Gene

IDBG-12133 (NLRC3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0031396	regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032496	response to lipopolysaccharide
GO:0042110	T cell activation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7RTR2

PhosphoSite