InnateDB Protein
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IDBP-12180.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PI4K2B
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Protein Name
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phosphatidylinositol 4-kinase type 2 beta
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264864
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InnateDB Gene
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IDBG-12178 (PI4K2B)
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Protein Structure
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Function |
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269PubMed:11923287}.
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Subcellular Localization |
Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:11923287}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000403
Phosphatidylinositol 3-/4-kinase, catalytic domain
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PFAM |
PF00454
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PRINTS |
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PIRSF |
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SMART |
SM00146
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TCG2
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PhosphoSite |
PhosphoSite-Q8TCG2
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TrEMBL |
G5E9Z4
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UniProt Splice Variant |
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Entrez Gene |
55300
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UniGene |
Hs.741411
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RefSeq |
NP_060793
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HUGO |
HGNC:18215
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OMIM |
612101
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CCDS |
CCDS3433
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HPRD |
15132
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IMGT |
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EMBL |
AC104662
AC108218
AF411320
AK001967
AY065990
AY091514
BC051749
CH471069
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GenPept |
AAH51749
AAL04154
AAL47580
AAM12049
BAA92006
EAW92836
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