InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MADCAM1

Summary

InnateDB Protein

IDBP-12214.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MADCAM1

Protein Name

mucosal vascular addressin cell adhesion molecule 1

Synonyms

MACAM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000215637

InnateDB Gene

IDBG-12208 (MADCAM1)

Protein Structure

UniProt Annotation

Function

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. {ECO:0000269PubMed:8609404, ECO:0000269PubMed:8989586}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002687	positive regulation of leukocyte migration
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007568	aging
GO:0030198	extracellular matrix organization
GO:0030216	keratinocyte differentiation
GO:0050776	regulation of immune response
GO:0050900	leukocyte migration