Homo sapiens Protein: MADCAM1
Summary
InnateDB Protein IDBP-12216.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MADCAM1
Protein Name mucosal vascular addressin cell adhesion molecule 1
Synonyms MACAM1;
Species Homo sapiens
Ensembl Protein ENSP00000304247
InnateDB Gene IDBG-12208 (MADCAM1)
Protein Structure
UniProt Annotation
Function Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. {ECO:0000269PubMed:8609404, ECO:0000269PubMed:8989586}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0030198 extracellular matrix organization
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR015169 Adhesion molecule, immunoglobulin-like
PFAM PF09085
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13477
PhosphoSite PhosphoSite-Q13477
TrEMBL
UniProt Splice Variant
Entrez Gene 8174
UniGene
RefSeq NP_570118
HUGO HGNC:6765
OMIM 102670
CCDS CCDS12029
HPRD 00035
IMGT
EMBL AC005775 AY732484 BC137506 BC137507 BC142629 BC144065 CH471242 U43628 U80012 U80013 U80014 U80015 U80016 U82483
GenPept AAB02194 AAC13661 AAC51354 AAC62844 AAI37507 AAI37508 AAI42630 AAI44066 AAV33123 EAW61195