InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CREBBP

Summary

InnateDB Protein

IDBP-12342.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREBBP

Protein Name

CREB binding protein

Synonyms

CBP; KAT3A; RSTS;

Species

Homo sapiens

Ensembl Protein

ENSP00000262367

InnateDB Gene

IDBG-12340 (CREBBP)

Protein Structure

UniProt Annotation

Function

Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269PubMed:11154691, ECO:0000269PubMed:12738767, ECO:0000269PubMed:12929931, ECO:0000269PubMed:14645221, ECO:0000269PubMed:9707565}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.

Disease Associations

Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with KMT2A/MLL1; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.Rubinstein-Taybi syndrome 1 (RSTS1) [MIM:180849]: A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. {ECO:0000269PubMed:11331617, ECO:0000269PubMed:12114483, ECO:0000269PubMed:12566391, ECO:0000269PubMed:15706485}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 497 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	497 [view]
Protein-Protein	435 [view]
Protein-DNA	42 [view]
Protein-RNA	0
DNA-DNA	20 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016407	acetyltransferase activity
GO:0043426	MRF binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001666	response to hypoxia
GO:0006325	chromatin organization
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0008589	regulation of smoothened signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0016573	histone acetylation
GO:0018076	N-terminal peptidyl-lysine acetylation
GO:0030718	germ-line stem cell maintenance
GO:0032481	positive regulation of type I interferon production
GO:0042592	homeostatic process
GO:0042733	embryonic digit morphogenesis
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048511	rhythmic process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0000790	nuclear chromatin
GO:0000940	condensed chromosome outer kinetochore
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016604	nuclear body

Protein Structure and Domains

PDB ID

InterPro

IPR000197 Zinc finger, TAZ-type
IPR000433 Zinc finger, ZZ-type
IPR001487 Bromodomain
IPR003101 Coactivator CBP, KIX domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR010303 Domain of unknown function DUF902, CREBbp
IPR011011 Zinc finger, FYVE/PHD-type
IPR013178 Histone H3-K56 acetyltransferase, RTT109
IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking

PFAM