InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL2L10

Summary

InnateDB Protein

IDBP-12402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L10

Protein Name

BCL2-like 10 (apoptosis facilitator)

Synonyms

BCL-B; Boo; Diva;

Species

Homo sapiens

Ensembl Protein

ENSP00000260442

InnateDB Gene

IDBG-12400 (BCL2L10)

Protein Structure

UniProt Annotation

Function

Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. {ECO:0000269PubMed:11278245}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:11593390}. Nucleus membrane {ECO:0000269PubMed:11593390}.

Disease Associations

Tissue Specificity

Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. {ECO:0000269PubMed:11593390}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007283	spermatogenesis
GO:0007292	female gamete generation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane