Homo sapiens Protein: ADAM7 | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-12449.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | ADAM7 | ||||||||
Protein Name | ADAM metallopeptidase domain 7 | ||||||||
Synonyms | ADAM 7; ADAM-7; EAPI; GP-83; GP83; | ||||||||
Species | Homo sapiens | ||||||||
Ensembl Protein | ENSP00000175238 | ||||||||
InnateDB Gene | IDBG-12445 (ADAM7) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}. | ||||||||
Subcellular Localization | Membrane; Single-pass type I membrane protein. | ||||||||
Disease Associations | Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis. | ||||||||
Tissue Specificity | Not detected in healthy melanocytes. Expressed in melanoma cells. {ECO:0000269PubMed:21618342}. | ||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | |||||||||
InterPro |
IPR001590
Peptidase M12B, ADAM/reprolysin IPR001762 Blood coagulation inhibitor, Disintegrin IPR002870 Peptidase M12B, propeptide IPR006586 ADAM, cysteine-rich |
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PFAM |
PF01421
PF00200 PF01562 PF08516 |
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PRINTS |
PR00289
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PIRSF | |||||||||
SMART |
SM00050
SM00608 |
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TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q9H2U9 | ||||||||
PhosphoSite | PhosphoSite-Q9H2U9 | ||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 8756 | ||||||||
UniGene | Hs.116147 | ||||||||
RefSeq | NP_003808 | ||||||||
HUGO | HGNC:214 | ||||||||
OMIM | 607310 | ||||||||
CCDS | CCDS6045 | ||||||||
HPRD | 07391 | ||||||||
IMGT | |||||||||
EMBL | AF090327 AF215824 AK292492 | ||||||||
GenPept | AAC36742 AAG43987 BAF85181 | ||||||||