InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXM1

Summary

InnateDB Protein

IDBP-12459.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXM1

Protein Name

forkhead box M1

Synonyms

FKHL16; FOXM1B; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TGT3; TRIDENT;

Species

Homo sapiens

Ensembl Protein

ENSP00000342307

InnateDB Gene

IDBG-12457 (FOXM1)

Protein Structure

UniProt Annotation

Function

Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. {ECO:0000269PubMed:17101782, ECO:0000269PubMed:19160488, ECO:0000269PubMed:20360045}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	39 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0001558	regulation of cell growth
GO:0001570	vasculogenesis
GO:0001889	liver development
GO:0006281	DNA repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007049	cell cycle
GO:0008284	positive regulation of cell proliferation
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0042127	regulation of cell proliferation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046578	regulation of Ras protein signal transduction
GO:0051726	regulation of cell cycle
GO:0071156	regulation of cell cycle arrest
GO:0090344	negative regulation of cell aging
GO:2000377	regulation of reactive oxygen species metabolic process
GO:2000781	positive regulation of double-strand break repair