InnateDB Protein
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IDBP-12463.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FOXM1
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Protein Name
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forkhead box M1
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Synonyms
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FKHL16; FOXM1B; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TGT3; TRIDENT;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354492
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InnateDB Gene
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IDBG-12457 (FOXM1)
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Protein Structure
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Function |
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. {ECO:0000269PubMed:17101782, ECO:0000269PubMed:19160488, ECO:0000269PubMed:20360045}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
43
[view]
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Protein-Protein |
39
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000086
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G2/M transition of mitotic cell cycle
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GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0000278
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mitotic cell cycle
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GO:0001558
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regulation of cell growth
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GO:0006281
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DNA repair
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006978
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DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
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GO:0007049
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cell cycle
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GO:0008284
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positive regulation of cell proliferation
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GO:0032873
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negative regulation of stress-activated MAPK cascade
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GO:0042127
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regulation of cell proliferation
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0046578
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regulation of Ras protein signal transduction
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GO:0051726
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regulation of cell cycle
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GO:0071156
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regulation of cell cycle arrest
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GO:0090344
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negative regulation of cell aging
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GO:2000377
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regulation of reactive oxygen species metabolic process
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GO:2000781
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positive regulation of double-strand break repair
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Cellular Component |
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PDB ID |
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InterPro |
IPR001766
Transcription factor, fork head
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PFAM |
PF00250
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PRINTS |
PR00053
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PIRSF |
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SMART |
SM00339
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TIGRFAMs |
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Modification |
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SwissProt |
Q08050
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PhosphoSite |
PhosphoSite-Q08050
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TrEMBL |
A8K591
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UniProt Splice Variant |
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Entrez Gene |
2305
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UniGene |
Hs.239
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RefSeq |
NP_973732
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HUGO |
HGNC:3818
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OMIM |
602341
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CCDS |
CCDS8517
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HPRD |
03823
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IMGT |
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EMBL |
AK291206
BC006192
BC006529
BC012863
DQ022289
L16783
U74612
U74613
U83113
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GenPept |
AAC37541
AAC51128
AAC51129
AAC63595
AAH06192
AAH06529
AAH12863
AAY26401
BAF83895
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