InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTNND2

Summary

InnateDB Protein

IDBP-12572.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTNND2

Protein Name

catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

Synonyms

GT24; NPRAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000307134

InnateDB Gene

IDBG-12568 (CTNND2)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250, ECO:0000269PubMed:9971746}.

Subcellular Localization

Nucleus {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Perikaryon. Note=Colocalizes with CDK5 in the cell body of neuronal cells.

Disease Associations

Tissue Specificity

Predominantly expressed in brain; accumulates in cortical neurons (at protein level). {ECO:0000269PubMed:17009320}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0001763	morphogenesis of a branching structure
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007612	learning
GO:0016337	single organismal cell-cell adhesion
GO:0048167	regulation of synaptic plasticity