InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VASN

Summary

InnateDB Protein

IDBP-12713.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VASN

Protein Name

vasorin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000306864

InnateDB Gene

IDBG-12711 (VASN)

Protein Structure

UniProt Annotation

Function

May act as an inhibitor of TGF-beta signaling. {ECO:0000269PubMed:15247411}.

Subcellular Localization

Membrane {ECO:0000305PubMed:15247411}; Single-pass type I membrane protein {ECO:0000305PubMed:15247411}. Secreted {ECO:0000269PubMed:15247411}.

Disease Associations

Tissue Specificity

Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells. {ECO:0000269PubMed:15247411}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0071456	cellular response to hypoxia
GO:0071461	cellular response to redox state

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000742 Epidermal growth factor-like domain
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003961 Fibronectin, type III

PFAM