InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtpap

Summary

InnateDB Protein

IDBP-127815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtpap

Protein Name

mitochondrial poly(A) polymerase

Synonyms

0610027A18Rik; AW551379; Papd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025077

InnateDB Gene

IDBG-127813 (Mtpap)

Protein Structure

UniProt Annotation

Function

Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0002134	UTP binding
GO:0003723	RNA binding
GO:0004652	polynucleotide adenylyltransferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0030145	manganese ion binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding