InnateDB Protein
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IDBP-128170.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rictor
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Protein Name
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RPTOR independent companion of MTOR, complex 2
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Synonyms
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4921505C17Rik; 6030405M08Rik; AVO3; AW492497; D530039E11Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000051809
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InnateDB Gene
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IDBG-128168 (Rictor)
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Protein Structure
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Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269PubMed:16221682, ECO:0000269PubMed:16962653, ECO:0000269PubMed:16962829, ECO:0000269PubMed:17141160}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
78 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1926007
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6QI06
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PhosphoSite |
PhosphoSite-Q6QI06
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
78757
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UniGene |
Mm.418173
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RefSeq |
NP_084444
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MGI ID |
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MGI Symbol |
Rictor
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OMIM |
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CCDS |
CCDS37032
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HPRD |
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IMGT |
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EMBL |
AC102825
AC158901
AK036149
AK075662
AK173326
AY497009
AY540053
BC058643
BC120903
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GenPept |
AAH58643
AAI20904
AAR89074
AAS46920
BAC29321
BAC35882
BAD32604
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