InnateDB Protein
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IDBP-128494.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Snrpd1
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Protein Name
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small nuclear ribonucleoprotein D1
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Synonyms
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AA407109; AL023031; SMD1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000002551
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InnateDB Gene
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IDBG-128492 (Snrpd1)
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Protein Structure
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Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
84 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98344
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InterPro |
IPR001163
Ribonucleoprotein LSM domain
IPR006649
Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920
Like-Sm (LSM) domain
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PFAM |
PF01423
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PRINTS |
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PIRSF |
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SMART |
SM00651
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TIGRFAMs |
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Modification |
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SwissProt |
P62315
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PhosphoSite |
PhosphoSite-P62315
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20641
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UniGene |
Mm.396467
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RefSeq |
NP_033252
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MGI ID |
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MGI Symbol |
Snrpd1
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OMIM |
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CCDS |
CCDS29056
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HPRD |
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IMGT |
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EMBL |
AK005517
AK007674
AK011455
AK013075
AK134582
AK135979
BC024875
M58558
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GenPept |
AAA96493
AAH24875
BAB24092
BAB25178
BAB27628
BAB28635
BAE22192
BAE22759
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