InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acy3

Summary

InnateDB Protein

IDBP-128640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acy3

Protein Name

aspartoacylase (aminoacylase) 3

Synonyms

0610006H10Rik; AA3; AAIII; Acy-3; AW107362; HCBP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050056

InnateDB Gene

IDBG-128638 (Acy3)

Protein Structure

UniProt Annotation

Function

Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids. {ECO:0000269PubMed:14656720, ECO:0000269PubMed:17012540}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:14656720}; Peripheral membrane protein {ECO:0000269PubMed:14656720}. Cytoplasm {ECO:0000269PubMed:14656720}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.

Disease Associations

Tissue Specificity

Expressed predominantly in kidney and to a lesser extent in liver. Weakly expressed in heart, small intestine, brain, lung, testis, and stomach. {ECO:0000269PubMed:14656720}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004046	aminoacylase activity
GO:0005515	protein binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0042802	identical protein binding
GO:0046872	metal ion binding