InnateDB Protein
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IDBP-128793.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Shroom4
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Protein Name
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shroom family member 4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000086949
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InnateDB Gene
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IDBG-128787 (Shroom4)
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Protein Structure
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Function |
Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II. {ECO:0000269PubMed:17009331}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:17009331}. Note=Shows partial colocalization with the cytoplasmic pool of F-actin.
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Disease Associations |
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Tissue Specificity |
Detected in most adult tissues examined. Expressed in brain, lung, heart, liver, kidney, muscle and ovary. Expressed throughout the brain, with high expression in the brain stem and cerebellum and weaker expression in the hypothalamus, the hippocampus and the olfactory bulb. Expressed in wide range of cell types during developpment, including vascular endothelium and the polarized epithelium of the neural tube and kidney. {ECO:0000269PubMed:16249884, ECO:0000269PubMed:17009331}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0051015
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actin filament binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2685570
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InterPro |
IPR014799
Apx/shroom, ASD2
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PFAM |
PF08687
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q1W617
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PhosphoSite |
PhosphoSite-Q1W617
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
208431
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UniGene |
Mm.23208
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RefSeq |
XP_006527610
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MGI ID |
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MGI Symbol |
Shroom4
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK173129
AL671501
BC151022
DQ435686
DQ435687
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GenPept |
AAI51023
ABD98016
ABD98017
BAD32407
CAM20542
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