InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxp2

Summary

InnateDB Protein

IDBP-128802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxp2

Protein Name

forkhead box P2

Synonyms

2810043D05Rik; AI449000; CAG-16; D0Kist7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031545

InnateDB Gene

IDBG-128800 (Foxp2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. {ECO:0000269PubMed:14701752, ECO:0000269PubMed:24179158}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0007519	skeletal muscle tissue development
GO:0009791	post-embryonic development
GO:0021549	cerebellum development
GO:0021757	caudate nucleus development
GO:0021758	putamen development
GO:0021987	cerebral cortex development
GO:0030324	lung development
GO:0040007	growth
GO:0042297	vocal learning
GO:0043010	camera-type eye development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048286	lung alveolus development
GO:0048745	smooth muscle tissue development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0060013	righting reflex
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis