InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asph

Summary

InnateDB Protein

IDBP-128918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asph

Protein Name

aspartate-beta-hydroxylase

Synonyms

2310005F16Rik; 3110001L23Rik; AI848629; AW261690; AW561901; BAH; C79816; cI-37;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077273

InnateDB Gene

IDBG-128916 (Asph)

Protein Structure

UniProt Annotation

Function

Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004597	peptide-aspartate beta-dioxygenase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007389	pattern specification process
GO:0008285	negative regulation of cell proliferation
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0018193	peptidyl-amino acid modification
GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031647	regulation of protein stability
GO:0032237	activation of store-operated calcium channel activity
GO:0033198	response to ATP
GO:0035108	limb morphogenesis
GO:0042264	peptidyl-aspartic acid hydroxylation
GO:0045862	positive regulation of proteolysis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0070588	calcium ion transmembrane transport
GO:0071277	cellular response to calcium ion
GO:0090316	positive regulation of intracellular protein transport
GO:0097202	activation of cysteine-type endopeptidase activity
GO:1901879	regulation of protein depolymerization

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0032541	cortical endoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:1914186

InterPro

IPR007803 Arginine/Asparagine/Proline hydroxylase
IPR007943 Aspartyl beta-hydroxylase/Triadin domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF05118
PF05279
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BSY0