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InnateDB Protein
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IDBP-131641.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rprd1a
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Protein Name
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regulation of nuclear pre-mRNA domain containing 1A
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000043618
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InnateDB Gene
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IDBG-131639 (Rprd1a)
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Protein Structure
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| Function |
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle (By similarity). {ECO:0000250}.
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
6 [view]
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Molecular Function |
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| Biological Process |
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GO:0070940
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dephosphorylation of RNA polymerase II C-terminal domain
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| Cellular Component |
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GO:0016591
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DNA-directed RNA polymerase II, holoenzyme
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| PDB ID |
MGI:2385066
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| InterPro |
IPR006569
CID domain
IPR006903
RNA polymerase II-binding domain
IPR008942
ENTH/VHS
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| PFAM |
PF04818
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| PRINTS |
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| PIRSF |
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| SMART |
SM00582
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q8VDS4
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| PhosphoSite |
PhosphoSite-Q8VDS4
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
225283
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| UniGene |
Mm.485708
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| RefSeq |
NP_659110
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| MGI ID |
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| MGI Symbol |
Rprd1a
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| OMIM |
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| CCDS |
CCDS29102
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| HPRD |
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| IMGT |
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| EMBL |
AK220475
BC021395
BC023084
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| GenPept |
AAH21395
AAH23084
BAD90282
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Version 5.4