InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdk13

Summary

InnateDB Protein

IDBP-131937.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk13

Protein Name

cyclin-dependent kinase 13

Synonyms

2310015O17Rik; Cdc2l5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036013

InnateDB Gene

IDBG-131935 (Cdk13)

Protein Structure

UniProt Annotation

Function

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. {ECO:0000269PubMed:17261272}.

Subcellular Localization

Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0030097	hemopoiesis
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain

Cellular Component

GO:0002945	cyclin K-CDK13 complex
GO:0005615	extracellular space
GO:0016607	nuclear speck
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex

Protein Structure and Domains

PDB ID

MGI:1916812

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt