Version 5.4
Homo sapiens Protein: GALNT8
Summary
InnateDB Protein IDBP-13199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GALNT8
Protein Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000252318
InnateDB Gene IDBG-13197 (GALNT8)
Protein Structure
UniProt Annotation
Function Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in heart, skeletal muscle, kidney, liver, small intestine and placenta. Weakly expressed in colon, thymus, spleen, lung and leukocyte. {ECO:0000269PubMed:10767557}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000772 Ricin B lectin domain
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF00652
PF14200
PF00535
PRINTS
PIRSF
SMART SM00458
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NY28
PhosphoSite PhosphoSite-Q9NY28
TrEMBL Q68VJ3
UniProt Splice Variant
Entrez Gene 3742
UniGene Hs.608547
RefSeq NP_059113
HUGO HGNC:4130
OMIM 606250
CCDS CCDS8533
HPRD 09374
IMGT
EMBL AJ271385 AJ505959 BC140888 BC140889
GenPept AAI40889 AAI40890 CAB89199 CAD44539

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca