InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RALA

Summary

InnateDB Protein

IDBP-13212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RALA

Protein Name

v-ral simian leukemia viral oncogene homolog A (ras related)

Synonyms

RAL;

Species

Homo sapiens

Ensembl Protein

ENSP00000005257

InnateDB Gene

IDBG-13210 (RALA)

Protein Structure

UniProt Annotation

Function

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. {ECO:0000269PubMed:18756269, ECO:0000269PubMed:19306925, ECO:0000269PubMed:20005108}.

Subcellular Localization

Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0031755	Edg-2 lysophosphatidic acid receptor binding

Biological Process

GO:0000910	cytokinesis
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0006913	nucleocytoplasmic transport
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0015031	protein transport
GO:0016032	viral process
GO:0017157	regulation of exocytosis
GO:0031532	actin cytoskeleton reorganization
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051491	positive regulation of filopodium assembly
GO:0051665	membrane raft localization
GO:0061024	membrane organization

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0030496	midbody
GO:0030659	cytoplasmic vesicle membrane
GO:0032154	cleavage furrow
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt