Version 5.4
Mus musculus Protein: Mybl1
Summary
InnateDB Protein IDBP-132529.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mybl1
Protein Name myeloblastosis oncogene-like 1
Synonyms A-myb; G1-419-6; repro9;
Species Mus musculus
Ensembl Protein ENSMUSP00000086034
InnateDB Gene IDBG-132527 (Mybl1)
Protein Structure
UniProt Annotation
Function Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Predominantly in the testis. Very low levels in the ovaries, spleen and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:99925
InterPro IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR012642 Transcription regulator Wos2-domain
IPR015395 C-myb, C-terminal
IPR017877 Myb-like domain
PFAM PF00249
PF07988
PF09316
PRINTS
PIRSF
SMART SM00717
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51960
PhosphoSite PhosphoSite-P51960
TrEMBL Q6LC31
UniProt Splice Variant
Entrez Gene 17864
UniGene Mm.479
RefSeq NP_032677
MGI ID
MGI Symbol Mybl1
OMIM
CCDS CCDS35510
HPRD
IMGT
EMBL BC103533 L35261 U90890 X82327
GenPept AAA62182 AAC53141 AAI03534 CAA57771

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca