InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sap130

Summary

InnateDB Protein

IDBP-132728.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sap130

Protein Name

Sin3A associated protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025109

InnateDB Gene

IDBG-132726 (Sap130)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0043966	histone H3 acetylation

Cellular Component

GO:0030914

STAGA complex

Protein Structure and Domains

PDB ID

MGI:1919782

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BIH0

PhosphoSite

PhosphoSite-Q8BIH0

TrEMBL

UniProt Splice Variant

Entrez Gene

269003

UniGene

RefSeq

NP_766553

MGI ID

MGI Symbol

Sap130

OMIM

CCDS

CCDS57117

HPRD

IMGT

EMBL

AK011978 AK053675 AK084078 BC063075 BC066030

GenPept

AAH63075 AAH66030 BAB27953 BAC35469 BAC39113