InnateDB Protein
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IDBP-133030.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cops5
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Protein Name
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COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
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Synonyms
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AI303502; CSN5; Jab1; Mov34; Sgn5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027050
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InnateDB Gene
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IDBG-133028 (Cops5)
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Protein Structure
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Function |
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:10721695}. Nucleus {ECO:0000269PubMed:10721695}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Note=Nuclear localization is diminished in the presence of IFIT3. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:10721695}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 668 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
668 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1349415
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InterPro |
IPR000555
JAB1/MPN/MOV34 metalloenzyme domain
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PFAM |
PF01398
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PRINTS |
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PIRSF |
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SMART |
SM00232
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TIGRFAMs |
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Modification |
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SwissProt |
O35864
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PhosphoSite |
PhosphoSite-O35864
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TrEMBL |
Q3V0K7
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UniProt Splice Variant |
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Entrez Gene |
26754
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UniGene |
Mm.474110
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RefSeq |
NP_038743
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MGI ID |
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MGI Symbol |
Cops5
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OMIM |
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CCDS |
CCDS14818
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HPRD |
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IMGT |
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EMBL |
AF065386
AF068223
AK012499
AK133073
AK146271
AK151492
BC046753
U70736
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GenPept |
AAC17179
AAD03470
AAF61318
AAH46753
BAB28282
BAE21497
BAE27030
BAE30445
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