InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gja10

Summary

InnateDB Protein

IDBP-133222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gja10

Protein Name

gap junction protein, alpha 10

Synonyms

Cx-57; cx57; Cx59;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061742

InnateDB Gene

IDBG-133220 (Gja10)

Protein Structure

UniProt Annotation

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning. {ECO:0000269PubMed:15147297, ECO:0000269PubMed:16820008, ECO:0000269PubMed:17681699, ECO:0000269PubMed:18320035}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17681699}; Multi-pass membrane protein {ECO:0000269PubMed:17681699}. Cell junction, gap junction {ECO:0000269PubMed:17681699}.

Disease Associations

Tissue Specificity

Low levels were detected in skin, heart, kidney, testis, ovary, intestine. Expression not detected in brain, sciatic nerve or liver. According to PubMed:15147297 expression is detected only in horizontal cells in the inner nuclear layer of the retina and not in other neurons of the central nervous system or tissues. Detected in the outer plexiform layer of the retina (at protein level). {ECO:0000269PubMed:12881038, ECO:0000269PubMed:15147297, ECO:0000269PubMed:17681699}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005243	gap junction channel activity

Biological Process

GO:0007154	cell communication
GO:0007276	gamete generation
GO:0007416	synapse assembly
GO:0009416	response to light stimulus
GO:0050908	detection of light stimulus involved in visual perception
GO:0055085	transmembrane transport