InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scyl1

Summary

InnateDB Protein

IDBP-133328.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scyl1

Protein Name

SCY1-like 1 (S. cerevisiae)

Synonyms

2810011O19Rik; C85140; mdf; mfd; Ntkl; p105;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025890

InnateDB Gene

IDBG-133326 (Scyl1)

Protein Structure

UniProt Annotation

Function

Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:11118629, ECO:0000269PubMed:12783284}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Golgi apparatus, cis-Golgi network {ECO:0000250}. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner. {ECO:0000250}.

Disease Associations

Note=Defects in Scyl1 are the cause of the muscle deficient phenotype (mdf). Mice exhibit progressive neuromuscular atrophy, hindlimb paralysis, gait ataxia, abnormal hindlimb posture and tremor. Pathology of mdf comprises cerebellar atrophy, Purkinje cell loss and optic nerve atrophy. {ECO:0000269PubMed:17571074}.

Tissue Specificity

Expressed in diaphragm, quadriceps, thymus, liver, lung, spleen, kidney, heart and brain. Prominently expressed in neurons, and enriched at central nervous system synapses and neuromuscular junctions. {ECO:0000269PubMed:11118629, ECO:0000269PubMed:17571074}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER

Cellular Component

GO:0005737	cytoplasm
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0005815	microtubule organizing center
GO:0016020	membrane
GO:0030126	COPI vesicle coat

Protein Structure and Domains

PDB ID

MGI:1931787

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt