InnateDB Protein
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IDBP-13397.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NAGPA
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Protein Name
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N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000310998
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InnateDB Gene
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IDBG-13395 (NAGPA)
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Protein Structure
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Function |
Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases. {ECO:0000269PubMed:23572527}.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000269PubMed:12058031}; Single-pass type I membrane protein {ECO:0000269PubMed:12058031}. Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:12058031}. Note=Cis/medial Golgi.
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Disease Associations |
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Tissue Specificity |
Isoform 2 may be brain-specific.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003944
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N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000742
Epidermal growth factor-like domain
IPR018711
Domain of unknown function DUF2233
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PFAM |
PF00008
PF09992
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PRINTS |
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PIRSF |
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SMART |
SM00181
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UK23
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PhosphoSite |
PhosphoSite-Q9UK23
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51172
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UniGene |
Hs.21334
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RefSeq |
NP_057340
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HUGO |
HGNC:17378
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OMIM |
607985
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CCDS |
CCDS10527
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HPRD |
12145
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IMGT |
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EMBL |
AC026458
AF187072
AK127952
AK314320
BC012194
CH471112
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GenPept |
AAF08273
AAH12194
BAG36968
BAG54605
EAW85245
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