Version 5.4
Mus musculus Protein: Kcns2
Summary
InnateDB Protein IDBP-134113.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcns2
Protein Name K+ voltage-gated channel, subfamily S, 2
Synonyms E130006J24Rik; Kv9.2;
Species Mus musculus
Ensembl Protein ENSMUSP00000072645
InnateDB Gene IDBG-134109 (Kcns2)
Protein Structure
UniProt Annotation
Function Potassium channel subunit. Modulates channel activity and reduces the ion flow. {ECO:0000269PubMed:9305895}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.
Disease Associations
Tissue Specificity Detected in brain, but not in the other tissues tested. Expression was highest in the olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1197011
InterPro IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003969 Potassium channel, voltage dependent, Kv6
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003973 Potassium channel, voltage dependent, Kv2
IPR003974 Potassium channel, voltage dependent, Kv3
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
PFAM PF02214
PF03521
PF00520
PF07885
PRINTS PR00169
PR01491
PR01492
PR01494
PR01495
PR01498
PIRSF
SMART SM00225
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35174
PhosphoSite PhosphoSite-O35174
TrEMBL Q8BPU9
UniProt Splice Variant
Entrez Gene 16539
UniGene
RefSeq NP_851834
MGI ID
MGI Symbol Kcns2
OMIM
CCDS CCDS27421
HPRD
IMGT
EMBL AF008574 AK048819 AK053281 AK087481 AK173110 BC059833
GenPept AAB72051 AAH59833 BAC33468 BAC35332 BAC39892 BAD32388

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca