InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BACH1

Summary

InnateDB Protein

IDBP-1353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BACH1

Protein Name

BTB and CNC homology 1, basic leucine zipper transcription factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000286800

InnateDB Gene

IDBG-1349 (BACH1)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0020037	heme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000117	regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ

PFAM

PF00170
PF07716
PF00651

PRINTS

PIRSF

SMART

SM00225
SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14867