InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCA7

Summary

InnateDB Protein

IDBP-13667.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA7

Protein Name

ATP-binding cassette, sub-family A (ABC1), member 7

Synonyms

ABCA-SSN; ABCX;

Species

Homo sapiens

Ensembl Protein

ENSP00000263094

InnateDB Gene

IDBG-13665 (ABCA7)

Protein Structure

UniProt Annotation

Function

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO:0000269PubMed:12917409, ECO:0000269PubMed:12925201, ECO:0000269PubMed:14570867, ECO:0000269PubMed:14592415}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow. {ECO:0000269PubMed:10873640, ECO:0000269PubMed:11435699, ECO:0000269PubMed:14592415}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0016887	ATPase activity
GO:0034188	apolipoprotein A-I receptor activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006909	phagocytosis
GO:0007613	memory
GO:0010875	positive regulation of cholesterol efflux
GO:0017121	phospholipid scrambling
GO:0018149	peptide cross-linking
GO:0032780	negative regulation of ATPase activity
GO:0032781	positive regulation of ATPase activity
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034380	high-density lipoprotein particle assembly
GO:0034504	protein localization to nucleus
GO:0038027	apolipoprotein A-I-mediated signaling pathway
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
GO:0050766	positive regulation of phagocytosis
GO:0055085	transmembrane transport
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:1900223	positive regulation of beta-amyloid clearance
GO:1901076	positive regulation of engulfment of apoptotic cell
GO:1902430	negative regulation of beta-amyloid formation
GO:1902995	positive regulation of phospholipid efflux

Cellular Component

GO:0000139	Golgi membrane
GO:0001891	phagocytic cup
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0032587	ruffle membrane
GO:0043190	ATP-binding cassette (ABC) transporter complex

Protein Structure and Domains

PDB ID

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011032 GroES (chaperonin 10)-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IZY2