InnateDB Protein
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IDBP-13667.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ABCA7
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Protein Name
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ATP-binding cassette, sub-family A (ABC1), member 7
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Synonyms
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ABCA-SSN; ABCX;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000263094
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InnateDB Gene
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IDBG-13665 (ABCA7)
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Protein Structure
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Function |
Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO:0000269PubMed:12917409, ECO:0000269PubMed:12925201, ECO:0000269PubMed:14570867, ECO:0000269PubMed:14592415}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the endoplasmic reticulum.
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Disease Associations |
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Tissue Specificity |
Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow. {ECO:0000269PubMed:10873640, ECO:0000269PubMed:11435699, ECO:0000269PubMed:14592415}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003439
ABC transporter-like
IPR003593
AAA+ ATPase domain
IPR011032
GroES (chaperonin 10)-like
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00005
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PRINTS |
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PIRSF |
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SMART |
SM00382
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IZY2
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PhosphoSite |
PhosphoSite-Q8IZY2
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TrEMBL |
E9PL63
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UniProt Splice Variant |
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Entrez Gene |
10347
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UniGene |
Hs.134514
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RefSeq |
NP_061985
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HUGO |
HGNC:37
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OMIM |
605414
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CCDS |
CCDS12055
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HPRD |
09255
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IMGT |
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EMBL |
AB055390
AC011558
AF140342
AF250238
AF311057
AF311058
AF311059
AF311060
AF311061
AF311062
AF311063
AF311064
AF311065
AF311066
AF311067
AF311068
AF311069
AF311070
AF311071
AF311072
AF311073
AF311074
AF311075
AF311076
AF311077
AF311078
AF311079
AF311080
AF311081
AF311082
AF311083
AF311084
AF311085
AF311086
AF311087
AF311088
AF311089
AF311090
AF311091
AF311092
AF311093
AF311094
AF311095
AF311096
AF311097
AF311098
AF311099
AF311100
AF311101
AF311102
AF328787
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GenPept |
AAF06727
AAF85794
AAK00959
AAN04657
BAB62294
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